INSIGHTS INTO TARGETING LKB1 IN TUMORIGENESIS

Insights into targeting LKB1 in tumorigenesis

Genetic alterations to serine-threonine kinase 11 (STK11) have been implicated in Peutz-Jeghers syndrome and tumorigenesis.Further exploration of the context-specific roles of liver kinase B1 (LKB1; encoded by STK11) observed that it regulates AMP-activated protein kinase (AMPK) and AMPK-related kinases.Given that both migration and proliferation a

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Deformation temperature impact on microstructure and mechanical properties uniformity of GWZ932K alloy under reciprocating upsetting-extrusion

At present, there are great technical difficulties in achieving microstructure and mechanical properties uniformity in large-size billets prepared by severe plastic deformation technology.How to improve the process route to realize the microstructure and mechanical properties uniformity of the billets has become an urgent problem to be solved at pr

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Comparison of antimicrobial efficacy of Calcipex and Metapex in endodontic treatment of chronic apical periodontitis: a randomised controlled trial study protocol

Introduction Various intracanal medicaments have been used in cases of chronic apical periodontitis for appropriate disinfection of the root canal system to eliminate microbes g25-660 focus st especially from the inaccessible areas.Calcium hydroxide is the most common intracanal medicament available in various forms, but its effectiveness with or w

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